By way of examples, Prof. Micah Murray’s research work makes use of high-density EEG data to alleviate the quality of life of mothers and improve our understanding of the consequences of preterm birth on sensory and cognitive development both during infancy and longitudinally through the adolescence of these children.
The EEG@Home project showcase: Independent physiological measurements of epilepsy patients from the comfort of their own homes

Andrea Biondi is a research scientist and PhD candidate in Clinical Neuroscience at King’s College London, at the Maurice Wohl Clinical Neuroscience Institute. He has a background in psychophysiology, neuroscience and psychopathology and has been a research scientist for the Remote Assessment of Disease and Relapse in Central Nervous System Disorders (RADAR-CNS) Project. His core expertise includes data acquisition from EEG, EEG-TMS and EEG-fMRI setups, EEG, ECG and EMG data analysis as well as psychological and cognitive assessments. Andrea is currently working on the EEG@Home research project, under the supervision of Prof. Mark Richardson and Prof. Deb Pal. Prof. Mark Richardson is the Head of the School of Neuroscience at the Institute of Psychiatry, Psychology & Neuroscience, King’s College London. He also heads the Richardson Lab where the primary focus is to study epilepsy and the origin of epileptic seizures, using brain imaging modalities such as EEG, fMRI, DTI as well as combined EEG-fMRI and TMS-EEG approaches. Prof. Deb Pal heads the Epilepsy and Neurodevelopmental Disorders Lab which focuses on global initiatives to personalize treatment based on genetic and precision medicine.
Existing approaches in epilepsy management
Epilepsy is a neurological disorder afflicting 65 million worldwide. It is characterized by recurrent seizures. Such epileptic seizures are often selfreported by people with epilepsy themselves and understanding the frequency and occurrence of these seizures is essential to define individual treatment plans. It is often very difficult for people with epilepsy to report their seizures accurately, which may be because events occur in sleep, or a period of confusion after a seizure may hinder accurate reporting. New approaches to improve the accuracy of seizures reporting through continuous monitoring of biosignals might therefore inform personalized treatment approaches and thereby improve the quality of life (QOL) of patients. Monitoring of physiological and behavioral factors such as muscle activity, electrical skin conductance, and heart rate can further inform the detection of seizures as these variables change before, during and after a seizure.
As part of the RADAR-CNS programme, Prof Richardson’s team has examined the feasibility and acceptability of wearable biosignal sensors in people with epilepsy (Bruno, 2018 and 2020a, 2020b; Simblett, 2020), and reviewed the currently available products in this domain (Bruno, 2020c).
Interviews were conducted to understand the experiences of the participants with biosensors during the RADAR-CNS study. Ease of application, concerns of data privacy and their perceived comfort and appearance were some key requirements highlighted by people with epilepsy. Furthermore, it is clear that there is not yet a fully-developed system for monitoring biosignals at home in people with epilepsy. The value of continuously monitored data could be extremely high: for example, Prof Richardson’s team is part of the My Seizure Gauge consortium, which has shown how the pattern of seizure occurrences self-reported by subjects in electronic diaries can be used forecast clinical electrographic seizures (Karoly, 2020).
Studies have provided strong evidence that video EEG monitoring is the gold standard for epilepsy diagnosis. However, long term monitoring within the hospital setting increases patient costs and involves logistical issues such as ensuring correct placement of scalp electrodes and accurate positioning of the camera over long periods of recording. Consequently, there has been a great effort in the research and clinical domains to introduce a long term, mobile, home-monitoring technology, which is reliable, non-invasive, self-applicable and acceptable to people with epilepsy.
EEEG@Home
The EEG@Home procedure aims to investigate the reliability and feasibility of frequent physiological measurements performed by epilepsy patients independently, from the comfort of their own homes. Data will be recorded with an ANT Neuro eegoTM 8 channel system, in combination with a wrist-worn smartwatch (the FitBit Charge 3) and on a smartphone application developed by Seer Medical. The outcomes of this study could bolster understanding of the individual seizure cycles and seizure triggers, thereby leading to new strategies for daily assessment and targeted therapies. Overall, such an endeavor will provide further support for people with epilepsy to cope better with the unpredictability of epileptic seizures, reduce anxieties and allow more independence in their activities of daily living.
Study Overview
This observational study plans to enroll 12 participants with epilepsy who were referred to the epilepsy clinics at King’s College Hospital and partner hospitals as part of their routine clinical care. The enrolled participants will be introduced to the EEG acquisition system, wrist worn smartwatch and smartphone app during their 1st introductory and training visit. Following this, monthly follow-up visits (visit 2-7) will be scheduled every month in the participant’s home or the research facility as per preference. The final assessment of usability and acceptability of the technology will be conducted after the last (7th) visit through questionnaires and a 15 minute interview.

Figure 1: A diagram that summarises how the EEG@HOME study works. The left part of the diagram contains icons that represent how measurements are taken: via EEG cap (ANT Neuro 8 channel waveguard™ touch dry EEG cap), smartphone app (SeerMedical) and smartwatch (FitBit Charge4). The middle part of the diagram contains icons representing the different measurements recorded: scalp EEG, heart rate, seizure occurrence, medication taken, sleep quality, stress and mood. The right part of the diagram finally represents the aim of the study; using all the information collected to prospectively identify periods of higher seizure risk and to improve the management of epilepsy.
Figure 2. An eHealth model of new technology for patients with epilepsy - Every day, patients with epilepsy face the possibility of having a seizure or other stressful life events that could affect their mood, sleep and behaviour. The continuous use of wearables and e-diary to safety acquire noninvasive measurable variables that can be associated with the occurrence of their seizure will help patients in the management of their condition providing the doctor with reliable information to monitor and control their patient s therapy and improving the interaction between patients, caregivers and heath care providers. All the data collected could also allow the research teams to have reliable information for the develop of prediction algorithms and for the design of future feasible studies. (Biondi, 2021)
Technology to be used in the study
The eegoTMmini amplifier and the 8 channel waveguard™ touch cap solution provided to the participants will enable participants to wear the EEG cap twice daily, to perform a 10 minute recording with the eego software. The eego mini system meets several of the hard-set technical requirements outlined by Pinho and colleagues for EEG systems which could be deployed for clinical purposes, such as dry electrodes, signal resolution, sampling frequency, comfort, portability and event detection (Pinho, 2017).

Figure 3: ANT Neuro eego™ mini-series and ANT Neuro waveguard™ touch