Abstract
Highlights d In preterm babies, auditory evoked Delta-brushes (DBs) include gamma oscillations d Evoked DBs scalp topography depends on the physical characteristics of the auditory stimulus d Evoked oscillations are more widespread after the click compared to vocal stimulus d Evoked DBs prevail on the right but shift to the left with age after the vocal stimulus SUMMARY During the third trimester of gestation in humans, the auditory cortex displays spontaneous and auditory- evoked EEG patterns of intermittent local oscillatory activity nested in delta waves – delta brushes (DBs). To test whether the spatiotemporal dynamics of evoked DBs depends on stimulus type, we studied auditory evoked responses (AERs) to voice and ‘‘click’’ using 32-electrode EEG in 30 healthy neonates aged 30 to 38 post-menstrual weeks. Both stimuli elicited two peaks at approximately 250 ms and 600 ms, the second corre- sponding to the first principal components of the AER and the evoked DB. The DB showed stimulus- specific topography, temporal posterior and mid-temporal for ‘‘click’’, and mid-temporal and pre-central inferior for voice, and contained theta to gamma oscillations more widespread for the ‘‘click’’response. Gamma oscil- lations increased with age. AERs predominated on the right but shifted toward the left with age for voice response. Auditory evoked DBs may therefore underlie specific auditory processing during fetal development.
Authors
Kaminska, Anna and Arzounian, Dorothee and Delattre, Victor and Laschet, Jacques and Magny, Jean-François and Hovhannisyan, Shushanik and Mokhtari, Mostafa and Manresa, Antoine and Boissel, Anne and Ouss-Ryngaert, Elisabeth and Hertz-Pannier, Lucie and Chiron, Catherine and Wendling, Fabrice and Denoyer, Yves and Kuchenbuch, Mathieu and Dubois, Jessica and Khazipov, Roustem
https://doi.org/10.1016/j.isci.2025.112313